Background: Numerous studies have explored factors associated with diagnostic errors in neuroradiology; however, large-scale multivariable analyses are lacking. Objective: To evaluate associations of interpretation time, shift volume, care setting, day of week, and trainee participation with diagnostic errors by neuroradiologists at a large academic medical center. Conclusion: Diagnostic errors in neuroradiology were associated with longer interpretation times, higher shift volumes, and weekend interpretation. Clinical Impact: These findings should be considered when designing workflow-related interventions seeking to reduce neuroradiology interpretation errors.