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Rheumatology Medical Article: Effect of ONO-5334 on bone mineral density and biochemical markers of bone turnover in postmenopausal osteoporosis: 2-year results from the OCEAN study (Effect of ONO-5334 on bone mineral density and biochemical... 
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A resource dedicated to disseminating reputable education materials to patients with rheumatic disease.
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The reactivity to COMP is yet another example of how, in addition to collagen II and the large aggregating proteoglycan, cartilage-specific proteins can induce arthritis and contribute to autoimmunity.
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Identification of patients who are in early stages of lupus is currently done through clinical evaluation and is not greatly facilitated by available diagnostic tests.
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Ultrastructure and Innervation of Thumb Carpometacarpal Ligaments in Surgical Patients With #Osteoarthritis http://t.co/bD0Dx1Z5vl
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Rheumatology Medical Article: Phase 1, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus (Phase 1, randomized, double-blind, placebo-controlled,...
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“A University of Michigan Medical School rheumatologist and his colleagues are beginning to comprehend how identical twins can be so different when it comes to the development of diseases such as rheumatoid arthritis. This newfound understanding and appreciation stems from the recent findings of three over-expressed genes in RA that were not previously linked with the ailment. This discovery could provide the necessary avenues for understanding the widely variable nature of RA and open the door for new and improved treatment.”
“Rheumatoid arthritis is a painful, chronic disease that affects about two-million Americans. It's also genetic -- but most of the time, only one twin in a pair will inherit it.”
"They look the same ... sound the same ... and share the same genetic code. But what has stumped scientists -- why some of them develop genetic diseases while their twin stays healthy. "That brings the question whether there is beyond the genes, whether there is another factor that is playing a role," says Joseph Holoshitz, M.D. and rheumatologist at the University of Michigan." http://bit.ly/1e7DklI
Via The New Media Moguls
Paul Kroeger's curator insight,
September 28, 2013 11:17 AM
ABOUT THE STUDY: The advantage of studying twins is that they start out with the same genetic information, so differences in the way the genes act can be attributed to differences in the person's surroundings. Those differences could cause a random genetic mutation, or affect how DNA is packaged. Only 15% of identical twins will both develop as rheumatoid arthritis. To find out why, the UM scientists compared gene expression patterns of 11 pairs of monozygotic twins who shared the same egg and were genetically identical, but only one of them had rheumatoid arthritis. In addition to the three new overexpressed genes, the researchers also found that non-genetic factors influenced the action of these genes, and that if only one twin in the family had rheumatoid arthritis, the actions of the genes were different than if neither twin had rheumatoid arthritis.
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This week from BMJ Learning: A 70 year old woman with heart failure has just been discharged after her fourth hospital admission in three months. She is tolerating her medication, which includes ma...
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Rheumatology Medical Article: Genes expressed in blood link osteoarthritis with apoptotic pathways (Genes expressed in blood link osteoarthritis with apoptotic pathways: Annals of Rheumatic Diseases http://t.co/ZP7jWyA8GL...
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Rheumatology Medical Article: Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis (Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumato...
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Rheumatology Medical Article: Changes in chemokines and their receptors in blood during treatment with the TNF inhibitor infliximab in patients with rheumatoid arthritis (Changes in chemokines and their receptors in blood during treatment with the...
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About a year ago I (and Brian Walitt) had an email conversation with a senior editor at Nature Reviews Rheumatology (NRR). She had written to me to ask for some advice about an article she was considering.
Gilbert C FAURE's insight:
sensitive topic... !
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From
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Rheumatology 2.0, by Carlo V Caballero: updated automatically with a curated selection of articles, blog posts, videos and photos. (RT @carvicab: Rheumatology 2.0 is out!
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Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. High prevalence of DM and anti-Mi-2 in Central America is thought to be associated ...
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Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study - up-to-the-minute news and headlines.
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Dr. Reichlin in his laboratory Dr. Reichlin and his wife, Marianne, on a visit to Australia. Drs. Scofield and Reichlin perform on their trumpets at a holiday gathering. Dr. Reichlin left at a gathering of immunologists in Vienna.
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Frontiers | Interferons in Sjögren’s syndrome: genes, mechanisms, and effects | Frontiers in Molecular Innate Immunity publishes articles on the most outstanding discoveries across the research spectrum of Frontiers | Interferons in Sjögren’s...
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Comparison of Health-Related Quality of Life...and Costs According to Hip and Knee Joint Disease Severity: http://t.co/ahnyDrfgg0
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Authors: T Tiippana-Kinnunen, H Kautiainen, L Paimela, M Leirisalo-Repo, Discipline: Medicine, Type: Journal Article (Co-morbidities in Finnish patients with rheumatoid arthritis: 15-year follow-up.: Scandin...
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Rheumatology Medical Article: Electroarthrography: a novel method to assess articular cartilage and diagnose osteoarthritis by non-invasive measurement of load-induced electrical potentials at the surface of the knee (Electroarthrography: a novel...
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Arthritis and diseases of the joints have been plaguing mankind since ancient times. For instance, in around 1500 BC, the Ebers Papyrus described a condition that is similar to rheumatoid arthritis.
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American College of Rheumatology (ACR) (Lupus starts between ages 20 and 30. #lupus http://t.co/XNJj4jyFLG)
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RT @AmiDauhoo: Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial - Online First... http://t.co/6uWycMyfXH
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PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Osteoarthritis (OA), a degenerative joint disease, affects millions of adults worldwide. There are many potential risk factors for OA, including several of interest in sports medicine: obesity, repetitive tasks (physical or ...
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